Ancient mtDNA Genetic Variants Modulate mtDNA Transcription and Replication
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چکیده
منابع مشابه
Ancient mtDNA Genetic Variants Modulate mtDNA Transcription and Replication
Although the functional consequences of mitochondrial DNA (mtDNA) genetic backgrounds (haplotypes, haplogroups) have been demonstrated by both disease association studies and cell culture experiments, it is not clear which of the mutations within the haplogroup carry functional implications and which are "evolutionary silent hitchhikers". We set forth to study the functionality of haplogroup-de...
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ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2009
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1000474